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| Directed by | ||
|---|---|---|
 | Tony Leondis | |
| Starring | ||
|---|---|---|
 | John Cusack voice | Igor |
 | Myleene Klass voice | Dr. Holzwurm |
| Robin Howard voice | Dr. Holzwurm's Igor |
| Matt McKenna voice | Dr. Herzschlag |
 | John Cleese voice | Dr. Glickenstein |
| Steve Buscemi voice | Scamper |
| Sean Hayes voice | Brain |
| Jess Harnell voice | Announcer / Royal Guard #2 |
 | Eddie Izzard voice | Dr. Schadenfreude |
| Jennifer Coolidge voice | Jaclyn / Heidi |
| Jay Leno voice | King Malbert |
| Molly Shannon voice | Eva |
| Zoe Bright voice | Blind Woman / Killiseum Fan #1 |
| Sophia Eraklis voice | Blind Orphan #1 |
| A. Cheron Hall voice | Blind Orphan #2 / Blind Orphan #4 |
| Alexander Leondis voice | Blind Orphan #3 |
| Juliana Leondis voice | Blind Orphan #5 |
| Michael Leondis voice | Blind Orphan #6 |
| Nicole Leondis voice | Blind Orphan #7 |
| Robin Tisserand voice | Blind Orphan #8 |
| Paul Vogt voice | Buzz Offmann |
| Kay Cole voice | Grand Dame |
| James Lipton | Self |
 | Christian Slater voice | Dr. Schadenfreude's Igor |
| Arsenio Hall voice | Carl Cristall |
| Tayah Howard voice | Tatiana |
| Justin Eick voice | Royal Guard #1 |
| John D. Eraklis voice | Killiseum Fan #2 |
| Max Howard voice | Killiseum Fan #3 |
| Tony Leondis voice | Killiseum Fan #4 |
| Chris McKenna voice | Killiseum Fan #5 |
| Rene Bitorajac uncredited | Igor |
| Christopher Maleki uncredited | Killiseum Fan #6 |
| Frank Welker uncredited | Animals' vocal effects |
5th April 2021
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United States release date: 19th September 2008
Israel release date: 2nd October 2008
Taiwan release date: 3rd October 2008
Philippines release date: 8th October 2008 United Kingdom release date: 17th October 2008
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